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Velakast Sofosbuvir 400mg + Velpatasvir 100mg Tablets

Velpatasvir Velakast tablets

Trade (patented) name of the drug:  Velakast

International (nonproprietary) name: sofosbuvir 400mg, velpatasvir 100mg

Manufacturer: Natco Pharma Ltd. , India

Dosage form and prescription

Film coated tablets for oral administration.

Composition

Active substance:  active substances are Velakast sofosbuvir and velpatasvir. Each tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. Inactive components: copovidone, sodium croscarmellose, magnesium stearate, microcrystalline cellulose., you can Buy Velakast Velpatasvir and sofosbuvir Tablets from India Online or you check price of velakast tablets in India.

The tablets are covered with a film shell. The composition of the shell includes the following inactive components: iron oxide red, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide.

Velpatasvir Velakast tablets

Trade (patented) name of the drug:  Velakast

International (nonproprietary) name: sofosbuvir 400mg, velpatasvir 100mg

Manufacturer: Natco Pharma Ltd. , India

Dosage form and prescription

Film coated tablets for oral administration.

Composition

Active substance:  active substances are Velakast sofosbuvir and velpatasvir. Each tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. Inactive components: copovidone, sodium croscarmellose, magnesium stearate, microcrystalline cellulose., you can Buy Velakast Velpatasvir and sofosbuvir Tablets from India Online or you check price of velakast tablets in India.

The tablets are covered with a film shell. The composition of the shell includes the following inactive components: iron oxide red, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide.

Pharmacological  group

Antiviral agent.

Indications for use:

A combination drug with a fixed dose of sofosbuvir, a nucleotide analog inhibiting HCV polymerase NS5B, and velpatasvir, a new NS5A inhibitor. The drug is intended for the treatment of chronic hepatitis C genotypes 1,2,3,4,5 and 6 in patients over 18 years

without liver cirrhosis or with compensated liver cirrhosis;

in decompensated liver cirrhosis with the combined use of ribavirin.

Contraindications:

Do not take this medicine and inform your doctor immediately if  You are allergic to sofosbuvir, velpatasvir, or any other component of the drug. Combined scheme of treatment with use of velpatasvir, sofosbuvir and ribavirin is contraindicated in patients with contraindications for the ribavirin.

Precautionary measures:

Before starting, inform your doctor about any existing diseases:

liver diseases other than hepatitis C;

severe renal disease or use of hemodialysis;

severe symptomatic bradycardia, in which sofosbuvir is prescribed in conjunction with amiodarone and other antiviral drug of direct action for the treatment of hepatitis C;

pregnancy or pregnancy planning (the effect of the drug on the fetus has not been studied);

women taking the drug in conjunction with ribavirin are not recommended to become pregnant during the course of treatment and 6 months after treatment. If pregnancy was discovered during combination therapy with sofosbuvir, and velpatasvir, you should immediately contact a doctor;

breast-feeding or planning (penetration of the drug into breast milk has not been studied);

Use in children: the drug is not recommended for children and adolescents under the age of 18 years, as data on the safety and efficacy of no.

Interaction with other drugs:

You should tell your doctor about any prescription or over-the-counter medications, vitamins or SUPPLEMENTS you are taking. This drug may interact with certain medications. Always warn the doctor about the beginning or termination of taking certain medicines. Do not take other drugs containing sofosbuvir (one of the active components of the drug).

P-glycoprotein inducers and / or moderate to strong inducers of CYP2B6, CYP2C8, and CYP3A4 (e.g. rifampicin, St. John’s wort, carbamazepine) may reduce the concentration of sofosbuvir and velpatasvir in the blood, which may reduce the therapeutic effect. The use of these drugs with sofosbuvir and velpatasvir not recommended.

Consult your doctor or pharmacist if you are taking medication for stomach ulcers, heartburn or acid reflux:

Antacid (magnesium/ aluminum hydroxide);

proton pump inhibitors (omeprazole);

H2-histamine receptor blockers (famotidine).

Tell your doctor or pharmacist if you are taking one of the following drugs:

Amiodarone for the treatment of arrhythmia; tenofovir disoproxil fumarate or any drug containing it used for the treatment of HIV; digoxin for the treatment of heart diseases; GMG-COA reductase inhibitors (rosuvastatin, atorvastatin).

Overdose:

In case of exceeding the dosage, the patient should be examined for signs of intoxication. Treatment in case of overdose consists of General support measures, including monitoring of vital functions, as well as monitoring of the clinical condition of the patient.

Method of application and doses:

Recommended dose. The recommended dose is one tablet a day before or after meals.

The recommended treatment regimen in patients with 1,2,3,4, 5 and 6 genotype.

Patients without cirrhosis or with compensated cirrhosis (cirrhosis of the liver grade A): velpatasvir + sofosbuvir 12 weeks

Patients with decompensated liver cirrhosis (liver cirrhosis class b and C): velpatasvir + sofosbuvir+ ribavirin 12 weeks

* In combination therapy, the recommended dose of ribavirin is calculated based on body weight (taken with food): 1000 mg per day for patients whose body weight is not more than 75 kg, and 1200 mg for patients whose body weight is more than 75 kg, divided into 2 doses. The dose at the beginning of treatment, as well as during treatment can be reduced, based on the indications of hemoglobin and creatinine clearance. To change the dose of ribavirin, it is necessary to read the instructions for use of the drug.

Release form and storage conditions:

Product: oval-shaped tablets, coated with a film shell engraved in the form of a six-pointed star on one side and dividing lines on the other. Packed in a plastic jar with a screw cap containing a first opening control mechanism, with a neck protected sealing membrane. The Bank contains 28 tablets.

Storage conditions:

* Keep out of reach of children.

* Store at temperatures below 30°C. Do not take the drug after the expiration date.

  • Store in the original package to protect from moisture.

Shelf life:

2 years.

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