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Form of production, composition and packaging
The tablets are coated with a blue color, diamond-shaped, slightly biconvex, with cut and rounded edges,. 1 tab. sildenafil (in the form of citrate) 50 mg.Excipients: microcrystalline cellulose, calcium hydrophosphate anhydrous, sodium croscarmellose, magnesium stearate, Opadry blue film coating and Opadry transparent, buy or check price of genric vigora 50mg rx sildenafil citrate tablets online from medimpex india
Clinical and pharmacological group: a Drug used in erectile dysfunction.
The drug for the treatment of erectile dysfunction. Sildenafil is a potent selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). Sildenafil does not have a direct relaxing effect on the isolated cavernous body, but enhances the relaxing effect of NO on this tissue by inhibiting PDE5, which is responsible for the decay of cGMP in the cavernous body.
Inhibition of PDE5 under the influence of sildenafil leads to an increase in the level of cGMP in the cavernous body, resulting in relaxation of smooth muscles and increased blood flow in the cavernous body. The use of sildenafil in recommended doses is ineffective in the absence of sexual stimulation. Selective sildenafil against PDE5 in vitro, its activity against PDE5 superior activity against other known isoforms of phosphodiesterases .
Against PDE5 sildenafil approximately 4000 times more active than camp – specific phosphodiesterase involved in the contraction of the myocardium. In some patients, 1 h after taking the drug at a dose of 100 mg with the help of the test Farnsworth-Munsell 100 revealed a slight and transient violation of the ability to distinguish shades of color (blue/green); 2 h after taking the drug, these changes were absent.
Color vision impairment is believed to be caused by inhibition of PDE6, which is involved in the process of light transmission in the retina. Sildenafil has no effect on visual acuity, contrast perception, electroretinogram, intraocular pressure or pupil diameter.